Ventricular septal defect associated with aneurysm of the membranous septum

J Am Coll Cardiol. 1985 Jan;5(1):118-23. doi: 10.1016/s0735-1097(85)80093-0.


The most common variety of ventricular septal defect, a perimembranous defect, is frequently associated with a so-called aneurysm of the membranous septum. Previous studies have suggested that ventricular septal defects associated with an aneurysm of the membranous septum tend to spontaneously decrease in size or close more than defects without such an aneurysm. To better define the natural history of this entity, clinical and catheterization data from 87 patients with ventricular septal defect and aneurysm of the membranous septum were reviewed. The initial evaluation was made at a median age of 0.3 years (range 0.1 to 11), with the final evaluation at a median age of 10 years (range 1.5 to 20) and a median duration of follow-up of 8.6 years (range 1.2 to 18.8). Approximately 75% of the ventricular septal defects had a small or no left to right shunt at last evaluation. Overall, 48 patients (55%) had no significant change in the size of the defect, and 39 (45%) showed improvement during the period of observation. Only four patients (5%) had spontaneous closure of the defect. Of the 49 patients who presented with a large left to right shunt, with or without congestive heart failure, 23 (47%) had persistence of a shunt large enough to warrant surgery. When spontaneous improvement occurred, it did so by 6 years of age in all but one patient. Therefore, a continued tendency for a ventricular septal defect associated with an aneurysm of the membranous septum to spontaneously decrease in size or close after this age may be less likely than previously suggested.(ABSTRACT TRUNCATED AT 250 WORDS)

MeSH terms

  • Aneurysm / complications*
  • Cardiac Catheterization
  • Cardiomyopathies / complications*
  • Child
  • Child, Preschool
  • Follow-Up Studies
  • Heart Failure / etiology
  • Heart Septal Defects, Ventricular / complications*
  • Heart Septal Defects, Ventricular / physiopathology
  • Heart Septum / physiopathology*
  • Humans
  • Infant
  • Membranes / physiopathology