Unveiling the biological functions and therapeutic potentials of LONP1 in the ovary

Yi Chen; Weian Mao; Yanting Shen; Honing Huang; Hsun-Ming Chang; Xi Dong; Jingjing Jiang; Liangshan Mu

doi:10.1016/j.molmed.2024.11.010

Unveiling the biological functions and therapeutic potentials of LONP1 in the ovary

Trends Mol Med. 2025 Jun;31(6):506-508. doi: 10.1016/j.molmed.2024.11.010. Epub 2024 Dec 7.

Authors

Yi Chen¹, Weian Mao², Yanting Shen³, Honing Huang⁴, Hsun-Ming Chang⁵, Xi Dong⁶, Jingjing Jiang⁷, Liangshan Mu⁸

Affiliations

¹ Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China; The First School of Medicine, Wenzhou Medical University, Wenzhou, China.
² Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
³ Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.
⁴ Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung, Taiwan.
⁵ Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung, Taiwan. Electronic address: 037841@tool.caaumed.org.tw.
⁶ Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address: dong.xi@zs-hospital.sh.cn.
⁷ Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address: jiang.jingjing@zs-hospital.sh.cn.
⁸ Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address: mu.liangshan@zs-hospital.sh.cn.

PMID: 39648053
DOI: 10.1016/j.molmed.2024.11.010

Abstract

Recent research highlights that Lon protease 1 (LONP1) regulates steroidogenesis in the ovary and plays a role in oocyte development and quality control. Dysregulation of LONP1 has been observed in polycystic ovary syndrome and ovarian aging. This forum article explores the role of LONP1 in the ovary and its therapeutic potential.

Keywords: Lon protease 1; mitochondria; ovarian aging; polycystic ovary syndrome.

MeSH terms

Animals
Female
Humans
Oocytes / metabolism
Ovary* / metabolism
Polycystic Ovary Syndrome* / genetics
Polycystic Ovary Syndrome* / metabolism