Acute and chronic effects of domperidone on gastric emptying in diabetic autonomic neuropathy

Dig Dis Sci. 1985 Jan;30(1):1-9. doi: 10.1007/BF01318363.


Gastric emptying was studied with a double radioisotopic method in 12 patients with insulin-dependent diabetes mellitus complicated by autonomic neuropathy and in 22 control subjects. In the diabetics, the acute and chronic effects of oral domperidone on gastric emptying, symptoms of gastroparesis, and glycemic control were assessed. Gastric emptying of solid and liquid was slower in diabetics than controls (P less than 0.001). Acute administration of domperidone increased the rate of both solid and liquid emptying (P less than 0.005). Domperidone was most effective in those patients with the greatest delay in gastric emptying. After chronic administration (35-51 days), domperidone had no significant effect on solid emptying (P greater than 0.05), but was still effective in increasing liquid emptying (P less than 0.025). Symptoms of gastroparesis were less after domperidone (P less than 0.001).

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Autonomic Nervous System Diseases / drug therapy
  • Autonomic Nervous System Diseases / physiopathology*
  • Blood Glucose / metabolism
  • Diabetes Mellitus, Type 1 / metabolism
  • Diabetes Mellitus, Type 1 / physiopathology*
  • Diabetic Neuropathies / drug therapy
  • Diabetic Neuropathies / physiopathology*
  • Domperidone / pharmacology
  • Domperidone / therapeutic use*
  • Female
  • Gastric Emptying / drug effects*
  • Humans
  • Male
  • Middle Aged
  • Paralysis / drug therapy
  • Paralysis / physiopathology
  • Stomach Diseases / drug therapy
  • Stomach Diseases / physiopathology
  • Time Factors


  • Blood Glucose
  • Domperidone