Protection From COVID-19 Vaccination and Prior SARS-CoV-2 Infection Among Children Aged 6 Months-4 Years, United States, September 2022-April 2023

J Pediatric Infect Dis Soc. 2025 Jan 20;14(1):piae121. doi: 10.1093/jpids/piae121.

Abstract

To understand how coronavirus disease 2019 vaccines impact infection risk in children <5 years, we assessed risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection from September 2022 to April 2023 in 3 cohort studies. There was no difference in risk by vaccination status. While vaccines reduce severe disease, they may not reduce SARS-CoV-2 infections in naïve young children.

Keywords: COVID-19; SARS-CoV-2; children; prior infection; vaccination.

MeSH terms

  • COVID-19 Vaccines*
  • COVID-19* / prevention & control
  • Child, Preschool
  • Cohort Studies
  • Female
  • Humans
  • Infant
  • Male
  • SARS-CoV-2* / immunology
  • United States / epidemiology
  • Vaccination

Substances

  • COVID-19 Vaccines