Carotenoids and vitamin A: the effect of hypocholesterolemic agents on serum levels

Metabolism. 1985 Jan;34(1):88-91. doi: 10.1016/0026-0495(85)90066-6.

Abstract

Serum total carotenoid (STC) and vitamin A levels were done as part of the biochemical screening in comparative studies of lipid lowering agents in type Ila hyperlipoproteinemic patients. STC levels were reduced following bile acid sequestering agent administration (colestipol 30 g/d) by 30% (P less than 0.01). Clofibrate and avicel placebo had inconsistent and nonsignificant effects on the STC levels. Serum vitamin A levels were not significantly altered by any of the test agents. The STC level changes were not correlated with concomitant changes in low-density lipoprotein-cholesterol (LDL-C) during any of the treatment regimens. It is suggested that STC level changes are related to alterations in the absorption of carotenoids during bile acid sequestrant administration.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Analysis of Variance
  • Anticholesteremic Agents / therapeutic use*
  • Carotenoids / blood*
  • Cellulose / pharmacology
  • Cholesterol, LDL / blood
  • Clofibrate / pharmacology
  • Colestipol / pharmacology
  • Humans
  • Hyperlipoproteinemia Type II / blood
  • Hyperlipoproteinemia Type II / drug therapy*
  • Middle Aged
  • Vitamin A / blood*

Substances

  • Anticholesteremic Agents
  • Cholesterol, LDL
  • Vitamin A
  • Carotenoids
  • Cellulose
  • Clofibrate
  • Colestipol