The hereditary transmission of high glutathione transferase activity towards trans-stilbene oxide in human mononuclear leukocytes

Hum Genet. 1985;69(1):66-8. doi: 10.1007/BF00295531.

Abstract

High glutathione transferase activity towards trans-stilbene oxide has been observed in resting mononuclear leukocytes only in a portion of the individuals examined. Approximately 46% of a population of 248 individuals demonstrated this high activity. In addition, eight families have been investigated in order to elucidate the hereditary transmission of this activity. The results are consistent with a dominant expression of a single gene located on an autosomal chromosome for this high glutathione transferase activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Child
  • Female
  • Genes, Dominant*
  • Glutathione Transferase / blood
  • Glutathione Transferase / genetics*
  • Humans
  • Male
  • Middle Aged
  • Monocytes / enzymology*
  • Pedigree
  • Phenotype
  • Stilbenes / metabolism*

Substances

  • Stilbenes
  • Glutathione Transferase
  • stilbene oxide