A Role for Anaphylactic Sensitization in Tumor Control

Int Arch Allergy Appl Immunol. 1985;76(1):20-4. doi: 10.1159/000233655.

Abstract

In order to evaluate the possible preventive role of an anaphylactic condition on tumor development, C57BL/6J mice were immunized or hyperimmunized by the intraperitoneal route with egg albumin in alum before the chemical induction of fibrosarcoma. Preimmunization using a protocol which elicits an optimal IgE response produced: (1) a significant reduction of tumor incidence; (2) an increase of survival time, and (3) a decrease of tumor growth rate in animals with higher IgE titers (greater than 640). On the other hand, hyperimmunized mice, which were suppressed in their anti-egg albumin IgE response, showed no changes in tumor incidence and survival time when compared to controls. Our results suggest a suppressive effect on tumor development related to the ability of the animal to mount an IgE response to antigens unrelated to the tumor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Immunization
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Neoplasms, Experimental / mortality
  • Neoplasms, Experimental / prevention & control*
  • Ovalbumin / immunology
  • Time Factors

Substances

  • Ovalbumin