Immunofluorescence studies in transient acantholytic dermatosis (Grover's disease)

Am J Dermatopathol. 1979 Winter;1(4):325-7. doi: 10.1097/00000372-197900140-00006.

Abstract

Abnormalities were found by immunofluorescence in five of 11 (45%) patients with transient acantholytic dermatosis. There was no consistent pattern to the abnormalities; for example, they were circulating antibodies to intercellular and basal cell antigens in a third. Deposits of Ig and/or C3 were present in lesions of three patients and C3 was present in the intercellular substance in the lesions of a fourth patient. These findings suggest that different immune mechanisms may be involved in the pathogenesis of transient acantholytic dermatosis.

MeSH terms

  • Acantholysis / immunology*
  • Acantholysis / pathology
  • Complement C3 / immunology
  • Fluorescent Antibody Technique
  • Humans
  • Immunoglobulin G / immunology
  • Immunoglobulin M / immunology
  • Skin Diseases / immunology*

Substances

  • Complement C3
  • Immunoglobulin G
  • Immunoglobulin M