Reduced high affinity cholecystokinin binding in hippocampus and frontal cortex of schizophrenic patients

Life Sci. 1985 Feb 4;36(5):473-7. doi: 10.1016/0024-3205(85)90260-7.

Abstract

Cholecystokinin (CCK) binding sites were assessed in post-mortem brain membrane preparations from controls and schizophrenic patients. 125I-BH CCK33 specific binding was reduced by 40% (p less than 0.02) in the hippocampus and by 20% (p less than 0.01) in the frontal cortex of schizophrenic patients compared with controls. There were no differences in 125I-BH CCK33 binding between the two groups in the amygdala, temporal cortex or caudate nucleus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Amygdala / metabolism
  • Binding Sites
  • Caudate Nucleus / metabolism
  • Cerebral Cortex / metabolism*
  • Cholecystokinin / metabolism*
  • Female
  • Hippocampus / metabolism*
  • Humans
  • Male
  • Middle Aged
  • Schizophrenia / metabolism*

Substances

  • Cholecystokinin