Chinese Medicines Treatment for Sleep Disturbance in Breast Cancer Survivors: A Network Meta-Analysis

Integr Cancer Ther. 2024 Jan-Dec:23:15347354241308857. doi: 10.1177/15347354241308857.

Abstract

Background: Sleep disturbance and insomnia are common adverse events in patients with breast cancer (BC). Traditional Chinese Medicine (TCM) treatment for sleep disturbance includes acupuncture, acupressure, auricular acupressure/auricular acupuncture, and Qigong. However, the specific efficacy of these TCM treatment remains unclear.

Materials and methods: This systematic review and network meta-analysis (NMA) investigated the effects of various TCM treatment on improving sleep quality in BC survivors.

Methods: Only randomized controlled trials (RCTs) reporting the results of TCM treatments were included. The main NMA included 12 RCTs involving 1011 participants. The risk of bias was assessed using the RoB 2 tool for randomized controlled trials. The certainty of evidence of the NMA was assessed in accordance with GRADE (the Grading of Recommendations, Assessment, Development, and Evaluations).

Results: Acupressure, acupuncture, auricular acupuncture/auricular acupressure, and qigong were identified as optimal TCM treatment (P < .05) for enhancing sleep quality in BC survivors.

Conclusion: Our results provide some evidence that TCM treatment, particularly acupressure, can be beneficial in improving sleep quality in BC survivors. However, larger-scale clinical trials with robust methodological designs are required to validate and extend our findings.

Keywords: breast cancer; insomnia; sleep disturbance; traditional Chinese medicine.

Publication types

  • Meta-Analysis
  • Systematic Review
  • Review

MeSH terms

  • Acupressure / methods
  • Acupuncture Therapy / methods
  • Breast Neoplasms* / complications
  • Breast Neoplasms* / drug therapy
  • Cancer Survivors* / statistics & numerical data
  • Drugs, Chinese Herbal / therapeutic use
  • Female
  • Humans
  • Medicine, Chinese Traditional / methods
  • Network Meta-Analysis*
  • Qigong / methods
  • Randomized Controlled Trials as Topic
  • Sleep Initiation and Maintenance Disorders / therapy
  • Sleep Wake Disorders* / etiology
  • Sleep Wake Disorders* / therapy

Substances

  • Drugs, Chinese Herbal