Intermembrane linkage mediated by tubulin

Biochem Biophys Res Commun. 1985 Jan 16;126(1):559-65. doi: 10.1016/0006-291x(85)90642-4.

Abstract

Two membranes from brain lipids were formed in the presence of brain tubulin and their electrical potentials were simultaneously measured. When electrical pulses were applied across one of them, displacements of the potential of the other membrane were found even when the membranes were not in contact. This effect was observed only in the presence of polymerized tubulin. It was not found in the presence of depolymerized tubulin or in other control experiments. The findings suggest that the microtubule fiber networks may serve as an interconnecting system between membranes or membrane bounded compartments.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Brain Chemistry
  • Electric Stimulation
  • Guanosine Triphosphate / metabolism
  • Lipid Bilayers / metabolism*
  • Lipid Metabolism
  • Polymers / metabolism
  • Time Factors
  • Tubulin / metabolism*

Substances

  • Lipid Bilayers
  • Polymers
  • Tubulin
  • Guanosine Triphosphate