N-Acetyltransferase phenotypes in the urinary bladder carcinogenesis of a low-risk population

Carcinogenesis. 1985 Feb;6(2):199-201. doi: 10.1093/carcin/6.2.199.

Abstract

N-Acetyltransferase phenotypes were measured in 228 patients with tumours of the urinary bladder and 100 non-cancer controls. 63.6% of the patients and 54.0% of the controls were slow acetylator phenotypes (p less than 0.10). In general, 65% of bladder tumour patients and 59% of controls are slow acetylators (p less than 0.025). N-Acetyltransferases are involved in the metabolism of carcinogenic arylamines and thus could be an important factor in interindividual susceptibility to these agents.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylation
  • Acetyltransferases / analysis*
  • Adult
  • Aged
  • Carcinogens / metabolism
  • Humans
  • Middle Aged
  • Phenotype
  • Risk
  • Urinary Bladder Neoplasms / enzymology*
  • Urinary Bladder Neoplasms / epidemiology

Substances

  • Carcinogens
  • Acetyltransferases