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. 1985 Feb 11;181(1):154-6.
doi: 10.1016/0014-5793(85)81132-7.

Complete Amino Acid Sequence of a New Type of Lethal Neurotoxin From the Venom of the Funnel-Web Spider Atrax Robustus

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Complete Amino Acid Sequence of a New Type of Lethal Neurotoxin From the Venom of the Funnel-Web Spider Atrax Robustus

D D Sheumack et al. FEBS Lett. .
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Abstract

Robustoxin, the lethal neurotoxin isolated from the venom of the male Sydney funnel-web spider, Atrax robustus, is of unique structural type and physiological mode of action. The primary structure of this 42-residue peptide was determined to be H2N-Cys-Ala-Lys-Lys-Arg-Asn-Trp-Cys-Gly-Lys-Asn-Glu-Asp-Cys-Cys-Cys-Pro- Met-Lys-Cys-Ile-Tyr-Ala-Trp-Tyr-Asn-Gln-Gln-Gly-Ser-Cys-Gln-Thr-Thr-Ile- Thr-Gly-Leu-Phe-Lys-Lys-Cys-H. The disposition of disulphide-bridged cysteine residues at both the amino- and carboxy-termini and as a triplet at residues 14-16 appears to have no precedent amongst neurotoxins.

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