Dabrafenib upregulates hypoglycosylated MUC1 and improves the therapeutic efficacy of Tn-MUC1 CAR-T cells

Affiliations

• ¹ Department of Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
• ² Laboratory Department, Dongguan Children's Hospital Affiliated to Guangdong Medical University, Dongguan 523000, China.
• ³ Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China.
• ⁴ Phase I Clinical Trial Center, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
• ⁵ Guangzhou Anjie Biomedical Technology Co. Ltd, Guangzhou 510535, China.
• ⁶ Guangdong Laboratory Animals Monitoring Institute, Guangzhou 510663, China.
• ⁷ Guangzhou Anjie Biomedical Technology Co. Ltd, Guangzhou 510535, China. Electronic address: hmikeyin@hotmail.com.
• ⁸ Department of Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China; Phase I Clinical Trial Center, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China; Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China. Electronic address: yaoherui@mail.sysu.edu.cn.
• ⁹ Breast Cancer Center, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou 310022, China. Electronic address: huhai@zjcc.org.cn.