TREM-1 and TREM-2 as therapeutic targets: clinical challenges and perspectives

Front Immunol. 2024 Dec 16:15:1498993. doi: 10.3389/fimmu.2024.1498993. eCollection 2024.

Abstract

TREM-1 and TREM-2 as Therapeutic Targets: Clinical Challenges and Perspectives.

Keywords: TREM-1; TREM-2; antagonists & inhibitors; clinical trial failure; drug discovery & development; inflammation; ligand-independent inhibition; multiligand receptors.

MeSH terms

  • Animals
  • Humans
  • Membrane Glycoproteins* / metabolism
  • Molecular Targeted Therapy
  • Receptors, Immunologic* / metabolism
  • Triggering Receptor Expressed on Myeloid Cells-1* / metabolism

Substances

  • Membrane Glycoproteins
  • Receptors, Immunologic
  • TREM1 protein, human
  • TREM2 protein, human
  • Triggering Receptor Expressed on Myeloid Cells-1