Intramitotic variation in proliferative potential: stochastic events in cellular aging

Mech Ageing Dev. 1985 Feb;29(2):143-9. doi: 10.1016/0047-6374(85)90014-4.


A series of mitotic pairs of cells were isolated and the proliferative potential of each cell determined. Although the proliferative potentials of the two cells of a single pair were similar for most pairs examined, in a significant proportion large differences were observed. These results suggest a strong stochastic component in the somatic inheritance of proliferative potential. This observation provides the basis for refinement of a mathematical model for in vitro cellular aging.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cell Division*
  • Cell Line
  • Cell Survival*
  • Fibroblasts / cytology
  • Humans
  • Mitosis*
  • Models, Biological
  • Probability*
  • Stochastic Processes*