Cryoelectron microscopy with elemental sensitivity

Hannah Ochner; Tanmay A M Bharat

doi:10.1016/j.str.2024.12.003

Cryoelectron microscopy with elemental sensitivity

Structure. 2025 Jan 2;33(1):13-14. doi: 10.1016/j.str.2024.12.003.

Authors

Hannah Ochner¹, Tanmay A M Bharat²

Affiliations

¹ Structural Studies Division, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
² Structural Studies Division, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. Electronic address: tbharat@mrc-lmb.cam.ac.uk.

PMID: 39753101
DOI: 10.1016/j.str.2024.12.003

Abstract

In a recent issue of Nature Methods, Pfeil-Gardiner et al. (2024)¹ combine electron energy-loss spectroscopy and single-particle cryoelectron microscopy to allow the spatially resolved imaging of the elemental composition of macromolecules.

MeSH terms

Cryoelectron Microscopy* / methods
Spectroscopy, Electron Energy-Loss / methods