Plasma cell and cancer stem cell crosstalk in glioblastoma

Cancer Cell. 2025 Jan 13;43(1):10-12. doi: 10.1016/j.ccell.2024.12.007. Epub 2025 Jan 2.

Abstract

Plasma cells (PCs) are the main producers of antibodies and have context-dependent roles in tumor immunity. In this issue of Cancer Cell, Gao et al. report that intratumoral PCs drive maintenance of glioblastoma stem cells to promote tumor growth via IgG secretion that activates a FcγRIIA-SYK-AKT signaling axis.

MeSH terms

  • Animals
  • Brain Neoplasms / immunology
  • Brain Neoplasms / metabolism
  • Brain Neoplasms / pathology
  • Glioblastoma* / immunology
  • Glioblastoma* / metabolism
  • Glioblastoma* / pathology
  • Humans
  • Neoplastic Stem Cells* / immunology
  • Neoplastic Stem Cells* / metabolism
  • Neoplastic Stem Cells* / pathology
  • Plasma Cells* / immunology
  • Plasma Cells* / metabolism
  • Plasma Cells* / pathology
  • Signal Transduction