HER2 and HER3 expression during neoadjuvant treatment of HER2-negative early breast cancer: potential for biomarker-driven sequencing of T-DXd and HER3-DXd

Cancer Commun (Lond). 2025 Apr;45(4):428-432. doi: 10.1002/cac2.12657. Epub 2025 Jan 6.

Christian Fridolin Singer^{1

2

3}, Stephan Wenzel Jahn⁴, Dominik Hlauschek³, Ulrike Maria Heber^{2

5}, Charlotte Mang-Manger², Daniel Egle^{3

6}, Marija Balic^{3

7

8}, Angelika Pichler⁹, Georg Pfeiler^{1

3}, Stephanie Kacerovsky-Strobl³, Christoph Suppan^{3

7}, Magdalena Ritter⁶, Edgar Petru¹⁰, Richard Greil^{3

11}, Zsuzsanna Bago-Horvath^{2

3

5}, Christine Deutschmann¹, Günther Georg Steger^{2

3}, Michael Seifert^{1

3}, Florian Fitzal^{3

12

13}, Rupert Bartsch^{2

3}, Anu Santhanagopal¹⁴, Jana Machacek-Link³, Dalila Sellami¹⁵, Magdalena Schwarz³, Christian Fesl³, Lidija Sölkner³, Stephen Esker¹⁵, Martin Filipits^{2

3

16}, Michael Gnant^{2

3}; Austrian Breast and Colorectal Cancer Study Group

¹ Department of Gynecology and Gynecological Oncology, Medical University of Vienna, Vienna, Austria.
² Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
³ Austrian Breast and Colorectal Cancer Study Group (ABCSG), Vienna, Austria.
⁴ Diagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria.
⁵ Department of Pathology, Medical University of Vienna, Vienna, Austria.
⁶ Department of Obstetrics and Gynecology, Medical University of Innsbruck, Innsbruck, Austria.
⁷ Division of Clinical Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
⁸ Division of Hematology/Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
⁹ Department of Internal Medicine Hematology and Internal Oncology, LKH Hochsteiermark-Leoben, Leoben, Austria.
¹⁰ Department of Gynecology and Obstetrics, Division of Gynecology, Medical University of Graz, Graz, Austria.
¹¹ Department of Internal Medicine III, Paracelsus Medical University Salzburg, Salzburg, Austria.
¹² Hanusch-Krankenhaus, Vienna, Austria.
¹³ Department of General Surgery, Medical University of Vienna, Vienna, Austria.
¹⁴ Global Oncology Medical Affairs, Daiichi Sankyo Inc., Basking Ridge, New Jersey, USA.
¹⁵ Research and Development, Daiichi Sankyo Inc., Basking Ridge, New Jersey, USA.
¹⁶ Center for Cancer Research, Medical University Vienna, Vienna, Austria.

No abstract available

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