A rabbit model of intracerebral hematoma

Acta Neuropathol. 1985;65(3-4):318-21. doi: 10.1007/BF00687015.


The epiphenomena that seem to cause deterioration and death after spontaneous interacerebral hematoma (SICH) might best be studied in an animal model. Therefore, the principles for developing such a model and techniques to study these phenomena were evaluated. Animals will tolerate injection of 3%-5% of their brain volume with a high proportion of clots. Fluorescein can be used to study the blood-brain barrier, and gravimetry to study edema. Others have found that injection of a paraffin/oil mixture can be employed for a control model. Refinement of the fluorescein technique, development of a primate model, and directions for future research are suggested.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood-Brain Barrier
  • Brain Edema / etiology
  • Brain Edema / metabolism
  • Cerebral Hemorrhage* / complications
  • Cerebral Hemorrhage* / metabolism
  • Disease Models, Animal*
  • Female
  • Fluorescein
  • Fluoresceins
  • Hematoma*
  • Humans
  • Male
  • Rabbits


  • Fluoresceins
  • Fluorescein