Lineage tracing senescence in vivo shows not all senescent cells are created equal

Dev Cell. 2025 Jan 6;60(1):3-4. doi: 10.1016/j.devcel.2024.12.008.

Abstract

Understanding the impact of senescence on disease is limited by the lack of tools to lineage label senescent cells. In a recent Cell issue, Zhao et al. create mouse models to genetically manipulate and trace p16+ cells, identifying contrasting roles for senescent macrophages and endothelial cells (ECs) in liver fibrosis.

MeSH terms

  • Animals
  • Cell Lineage*
  • Cellular Senescence*
  • Cyclin-Dependent Kinase Inhibitor p16 / genetics
  • Cyclin-Dependent Kinase Inhibitor p16 / metabolism
  • Endothelial Cells* / cytology
  • Endothelial Cells* / metabolism
  • Humans
  • Liver Cirrhosis / pathology
  • Macrophages* / cytology
  • Macrophages* / metabolism
  • Mice

Substances

  • Cyclin-Dependent Kinase Inhibitor p16