Frequency of diabetes mellitus in mothers of probands with gestational diabetes: possible maternal influence on the predisposition to gestational diabetes

Am J Obstet Gynecol. 1985 Feb 15;151(4):471-5. doi: 10.1016/0002-9378(85)90272-8.


Interviews for genetic histories were conducted prior to delivery in 166 pregnant diabetic probands and 83 control gravidas with normal carbohydrate metabolism throughout gestation. A significant association was observed between parental diabetic phenotypes and type of diabetes in the probands (chi 2(12)) = 32.413; p less than 0.001). In particular a higher than expected number of mothers with diabetes was encountered in 91 probands with gestational diabetes mellitus. The findings are examined in relationship to the hypothesis that vulnerability to gestational diabetes may be increased by exposure to an abnormal environment during intrauterine development.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Age Factors
  • Diabetes Mellitus / epidemiology
  • Diabetes Mellitus / genetics*
  • Diabetes Mellitus, Type 1 / genetics
  • Female
  • Glucose Tolerance Test
  • Humans
  • Medical History Taking
  • Pedigree
  • Pregnancy
  • Pregnancy Trimester, Second
  • Pregnancy in Diabetics / epidemiology
  • Pregnancy in Diabetics / genetics*
  • Prospective Studies
  • Sex Factors