We present an efficient synthetic pathway for kasugamycin, an aminoglycoside antibiotic, utilizing naturally derived carbohydrates as starting materials. This synthesis effectively addresses stereochemical complexities by employing the selective reduction of d-fucal, which generates a crucial 3-deoxyglycal intermediate. This intermediate facilitates the introduction of amino groups at the C-2 and C-4 positions, which is essential for the synthesis of kasugamine. Subsequent glycosylation with glycosyl 1-O-m-chlorobenzoate (mCBz) donors yields a disaccharide intermediate, which is further transformed to produce kasugamycin. This streamlined approach provides a practical and effective route for the synthesis of kasugamycin and related deoxy amino sugar-containing antibiotics.