Atypical presentations of pyridoxine-dependent seizures: a treatable cause of intractable epilepsy in infants

Ann Neurol. 1985 Feb;17(2):117-20. doi: 10.1002/ana.410170203.


We report on 3 patients with atypical pyridoxine-dependent seizures. Each had either late onset of convulsions (2 cases) or seizure-free intervals of up to several months' duration in the absence of pyridoxine supplementation. The findings, taken together with those in 9 previously reported cases, indicate that a trial of pyridoxine should be performed in all seizure disorders with onset before 18 months of age, regardless of type.

Publication types

  • Case Reports

MeSH terms

  • Child, Preschool
  • Electroencephalography
  • Epilepsy / drug therapy*
  • Female
  • Humans
  • Infant
  • Male
  • Pyridoxine / administration & dosage
  • Pyridoxine / therapeutic use*
  • Status Epilepticus / drug therapy


  • Pyridoxine