Deficits in manipulative behaviors induced by local injections of muscimol in the first somatosensory cortex of the conscious monkey

Brain Res. 1985 Jan 28;325(1-2):375-80. doi: 10.1016/0006-8993(85)90344-0.


Injection of muscimol (GABA agonist) in the finger region of area 2 of the alert monkey led to the striking yet reversible loss of finger coordination, thus disabling the monkey from picking up a small piece of food from a small hole or a funnel. Symptoms varied depending on sites of injection within the finger region. Neither weakness of hand or finger movements nor deficit in hand reach was observed.

MeSH terms

  • Animals
  • Brain Diseases / physiopathology
  • Brain Mapping
  • Female
  • Hand
  • Macaca
  • Motor Skills / drug effects
  • Motor Skills / physiology*
  • Muscimol / pharmacology*
  • Oxazoles / pharmacology*
  • Somatosensory Cortex / drug effects
  • Somatosensory Cortex / physiology*
  • gamma-Aminobutyric Acid / physiology*


  • Oxazoles
  • Muscimol
  • gamma-Aminobutyric Acid