Neoadjuvant Targeted Therapy in Non-Small Cell Lung Cancer and Its Impact on Surgical Outcomes

Mark Sorin; Caroline Huynh; Merav Rokah; Laurie-Rose Dubé; Roni Rayes; Linda Ofiara; Benjamin Shieh; Scott Owen; Pierre Olivier Fiset; Sophie Cammilleri-Broët; Sara Najmeh; Jonathan Cools-Lartigue; Lorenzo Ferri; Jonathan D Spicer

doi:10.1016/j.atssr.2022.11.014

Neoadjuvant Targeted Therapy in Non-Small Cell Lung Cancer and Its Impact on Surgical Outcomes

Ann Thorac Surg Short Rep. 2022 Nov 25;1(1):102-106. doi: 10.1016/j.atssr.2022.11.014. eCollection 2023 Mar.

Authors

Mark Sorin^{1

2}, Caroline Huynh^{1

3}, Merav Rokah³, Laurie-Rose Dubé⁴, Roni Rayes^{1

3}, Linda Ofiara⁵, Benjamin Shieh⁵, Scott Owen⁵, Pierre Olivier Fiset⁶, Sophie Cammilleri-Broët⁶, Sara Najmeh³, Jonathan Cools-Lartigue³, Lorenzo Ferri³, Jonathan D Spicer^{1

3}

Affiliations

¹ Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montréal, Quebec, Canada.
² Department of Human Genetics, McGill University Health Centre, Montréal, Quebec, Canada.
³ Department of Surgery, McGill University, Montréal, Quebec, Canada.
⁴ Faculty of Medicine, McGill University, Montréal, Quebec, Canada.
⁵ Department of Oncology, McGill University Health Centre, Montréal, Quebec, Canada.
⁶ Department of Pathology, McGill University, Montréal, Quebec, Canada.

Abstract

Background: The evidence for neoadjuvant targeted therapy in non-small cell lung cancer is limited, with 2 phase 3 trials currently recruiting and no approved indications.

Methods: We describe our experience with the use of neoadjuvant targeted therapy for patients with operable non-small cell lung cancer.

Results: Our focus is on surgical outcomes, which represent an underreported aspect of the patient trajectory. We argue that surgical outcomes are an essential feature of this strategy with significant potential benefits and risks.

Conclusions: Overall, the patient experience can be significantly affected by the use of neoadjuvant targeted therapy and its impact on surgical planning, strategy, and outcomes.