Social Connections, Leukocyte Telomere Length, and All-Cause Mortality in Older Adults From Costa Rica: The Costa Rican Longevity and Healthy Aging Study (CRELES)

J Aging Health. 2026 Jan;38(1-2):110-119. doi: 10.1177/08982643251313923. Epub 2025 Jan 10.

Abstract

ObjectivesTo examine the association of social connections with blood leukocyte telomere length (LTL) and all-cause mortality in older Costa Ricans.MethodsUtilizing data from the Costa Rican Longevity and Healthy Aging Study (CRELES), a prospective cohort of 2827 individuals aged 60 and above followed since 2004, we constructed a Social Network Index (SNI) based on marital status, household size, interaction with non-cohabitating adult children, and church attendance. We used linear regression to assess SNI's association with baseline LTL (N = 1113), and Cox proportional-hazard models to examine SNI's relationship with all-cause mortality (N = 2735).ResultsHigher SNI levels were associated with longer telomeres and decreased all-cause mortality during follow-up. Being married and regular church attendance were associated with 23% and 24% reductions of the all-cause mortality, respectively.DiscussionThese findings underscore the importance of social engagement in promoting longevity among older Costa Ricans, suggesting broader implications for aging populations globally.

Keywords: Costa Rica; longevity; mortality; social connections.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Costa Rica / epidemiology
  • Female
  • Healthy Aging*
  • Humans
  • Leukocytes*
  • Longevity*
  • Male
  • Middle Aged
  • Mortality* / trends
  • Proportional Hazards Models
  • Prospective Studies
  • Social Support*
  • Telomere*