Glycosylated haemoglobin in normal pregnancy: a longitudinal study with two independent methods

Diabetologia. 1985 Feb;28(2):76-9. doi: 10.1007/BF00279919.


Twenty-one women completed a longitudinal study of glycosylated haemoglobin in normal pregnancy. Glycosylated haemoglobin levels were measured using two independent techniques (ion-exchange column and colorimetric). Concurrent serial oral glucose tolerance tests (75-g glucose load) and erythrocyte indices were obtained. Changes in mean glycosylated haemoglobin were similar with both techniques with a nadir at 17 weeks, a peak at delivery (p less than 0.002 versus 17 weeks) and a fall post-partum. Glycosylated haemoglobin levels in abnormal pregnancies, e.g. diabetic, should be interpreted in the knowledge of these physiological changes.

MeSH terms

  • Adolescent
  • Adult
  • Blood Glucose / analysis
  • Chromatography, Ion Exchange
  • Colorimetry
  • Erythrocyte Indices
  • Female
  • Glucose Tolerance Test
  • Glycated Hemoglobin A / analysis*
  • Humans
  • Longitudinal Studies
  • Postpartum Period
  • Pregnancy Trimester, Second
  • Pregnancy Trimester, Third
  • Pregnancy*


  • Blood Glucose
  • Glycated Hemoglobin A