Frontal Fibrosing Alopecia (FFA) poses a distinct dermatological challenge with epithelial-mesenchymal transition (EMT) at its core, driving follicular cell transformation and fibrotic changes. Genetic studies highlight significant associations, while environmental triggers, such as implicated cosmetic products (sunblock, personal hair care products, and moisturizers), introduce complexity. Managing FFA proves daunting due to its chronic and unpredictable nature. Treatment strategies, including combination therapies including hydroxychloroquine, dutasteride, topical and intralesional steroids, and topical tacrolimus, offer hope in stabilizing the condition. Monitoring the disease progression may be challenging as no established guidelines exist, however, imaging techniques may offer help in the future.
Keywords: Alopecia; Dermatological disorder. Postmenopausal women; Epithelial-mesenchymal transition; Familial clustering; Finasteride; HLA profiles; Hair loss; Hydroxychloroquine; JAK inhibitors; Lichen planopilaris; Neurogenic inflammation; Scarring alopecia; Sunscreen; Topical corticosteroids.
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