Restimulation by macrophages exhausts T cells

Immunity. 2025 Jan 14;58(1):12-14. doi: 10.1016/j.immuni.2024.12.010.

Abstract

Inhibiting T cell exhaustion is an attractive cancer immunotherapy strategy. In this issue of Immunity, Waibl Polania et al. examine the microenvironmental signals regulating terminal T cell exhaustion and find that antigen presentation by tumor-associated macrophages, not tumor cells, drives terminal T cell exhaustion in glioblastoma.

Publication types

  • Comment

MeSH terms

  • Animals
  • Antigen Presentation / immunology
  • Glioblastoma* / immunology
  • Glioblastoma* / therapy
  • Humans
  • Immunotherapy / methods
  • Macrophages* / immunology
  • T-Lymphocytes* / immunology
  • Tumor Microenvironment / immunology
  • Tumor-Associated Macrophages* / immunology