Physiological and behavioral stability of newborns on therapeutic hypothermia for hypoxic-ischemic encephalopathy during parental holding

Abstract

Background: Physical separation contributes to parental trauma and poor bonding in the context of therapeutic hypothermia (TH) for hypoxic-ischemic encephalopathy (HIE). Parental holding (PH) may improve parents' experience. We aim to determine the physiological and behavioral stability of the newborn held by the parents during TH.

Methods: Observational, prospective, single-center study which included 30 newborns with mean gestational age of 39 (1.8) weeks and mean birth weight 3165 (508) g, with HIE treated by TH, whom parents wanted to hold. All infants were mechanically ventilated and received sedation-analgesia. Main outcome was change in body temperature (> 34°C or < 33 °C) during PH. Secondary outcomes were change in vital signs and behavior (comfort/pain scores) during PH. Parental and nurses' opinions were assessed by a self-reporting questionnaire with a 10-point Likert scale.

Results: We found no significant changes in temperature, other vital signs or in infants' COMFORT-B score during parental holding. Responses to self-reporting questionnaires completed by parents and nurses showed a high level of overall effectiveness and satisfaction with PH.

Conclusion: Parents holding newborns undergoing therapeutic hypothermia for hypoxic-ischemic encephalopathy was safe for the newborn without causing discomfort. It was also beneficial for the parents and supported by the healthcare team.

Impact: Parents holding newborns undergoing therapeutic hypothermia for Hypoxic Ischemic Encephalopathy was feasible without causing discomfort. It was also beneficial for the parents and supported by the healthcare team. Infants' temperature or other vital signs did not change during parental holding, which was found very satisfactory by parents and healthcare givers, showing that parental holding is feasible. This study promotes further dissemination of parental holding, which may limit the detrimental effect of physical separation for parents of newborns undergoing therapeutic hypothermia.