Attempt to fulfil Koch's postulates for pyloric Campylobacter

Med J Aust. 1985 Apr 15;142(8):436-9.

Abstract

A volunteer with histologically normal gastric mucosa received pyloric campylobacter by mouth. A mild illness developed, which lasted 14 days. Histologically proven gastritis was present on the tenth day after the ingestion of bacteria, but this had largely resolved by the fourteenth day. The syndrome of acute pyloric campylobacter gastritis is described. It is proposed that this disorder may progress to a chronic infection which predisposes to peptic ulceration.

MeSH terms

  • Achlorhydria / etiology
  • Acute Disease
  • Adult
  • Biopsy
  • Campylobacter / pathogenicity
  • Campylobacter Infections* / drug therapy
  • Campylobacter Infections* / microbiology
  • Chronic Disease
  • Gastric Mucosa / microbiology
  • Gastric Mucosa / pathology
  • Gastritis / drug therapy
  • Gastritis / etiology
  • Gastritis / microbiology*
  • Gastritis / pathology
  • Gastroscopy
  • Humans
  • Male
  • Peptic Ulcer / etiology
  • Pyloric Antrum / microbiology
  • Pyloric Antrum / pathology
  • Tinidazole / therapeutic use

Substances

  • Tinidazole