Compression neuropathy from muscle fibrosis induced by repeated meperidine injections

Plast Reconstr Surg. 1985 Apr;75(4):582-3.


The combination of myopathy and neuropathy with fibrosis and contractures has apparently not yet been reported from the use of meperidine. We describe a patient addicted to meperidine in whom bilateral hand numbness and weakness developed and electrodiagnostic studies revealed moderate slowing of motor nerve conduction velocities. Neurolysis of the median and ulnar nerves resulted in markedly improved symptoms.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Female
  • Humans
  • Injections, Intramuscular / adverse effects*
  • Median Nerve / physiopathology
  • Meperidine / administration & dosage*
  • Meperidine / adverse effects
  • Muscular Diseases / complications
  • Muscular Diseases / etiology*
  • Nerve Compression Syndromes / etiology*
  • Ulnar Nerve / physiopathology


  • Meperidine