Deep learning and generative artificial intelligence in aging research and healthy longevity medicine

Aging (Albany NY). 2025 Jan 16;17(1):251-275. doi: 10.18632/aging.206190. Epub 2025 Jan 16.

Abstract

With the global population aging at an unprecedented rate, there is a need to extend healthy productive life span. This review examines how Deep Learning (DL) and Generative Artificial Intelligence (GenAI) are used in biomarker discovery, deep aging clock development, geroprotector identification and generation of dual-purpose therapeutics targeting aging and disease. The paper explores the emergence of multimodal, multitasking research systems highlighting promising future directions for GenAI in human and animal aging research, as well as clinical application in healthy longevity medicine.

Keywords: aging; deep aging clocks; deep learning; generative artificial intelligence; healthy longevity medicine.

Publication types

  • Review

MeSH terms

  • Aging* / physiology
  • Animals
  • Artificial Intelligence*
  • Biomarkers
  • Deep Learning*
  • Generative Artificial Intelligence
  • Healthy Aging*
  • Humans
  • Longevity* / physiology

Substances

  • Biomarkers