History of the streptothricin antibiotics and evidence for the neglect of the streptothricin resistome

Ezabelle Franck; Terence S Crofts

doi:10.1038/s44259-023-00020-5

History of the streptothricin antibiotics and evidence for the neglect of the streptothricin resistome

NPJ Antimicrob Resist. 2024 Feb 7;2(1):3. doi: 10.1038/s44259-023-00020-5.

Authors

Ezabelle Franck¹, Terence S Crofts²

Affiliations

¹ Department of Biomedical Sciences, Florida State University, Tallahassee, FL, USA.
² Department of Biomedical Sciences, Florida State University, Tallahassee, FL, USA. tcrofts@fsu.edu.

Abstract

The streptothricin antibiotics were among the first antibiotics to be discovered from the environment and remain some of the most recovered antimicrobials in natural product screens. Increasing rates of antibiotic resistance and recognition that streptothricin antibiotics may play a role in countering so-called super-bugs has led to the re-evaluation of their clinical potential. Here we will review the current state of knowledge of streptothricins and their resistance in bacteria, with a focus on the potential for new resistance mechanisms and determinants to emerge in the context of potential widespread clinical adoption of this antibiotic class.

Publication types

Review