One of the tasks of adolescence is the development of a value system. The way in which these values are expressed in relationship to illness in adolescence, however, has not been studied. The authors conducted a social science survey to study the spiritual concerns of hospitalized adolescents. One hundred and fourteen hospitalized adolescents, ranging in age from 11 to 19, answered a Likert scale questionnaire on Spiritual and Religious Concerns (SRQ). Analysis of variance was performed to correlate responses with sex, race, religion, type of school, and severity of illness. A subgroup of hospitalized adolescents, those with more serious disease, experienced intensified spiritual and religious concerns. In response to the questionnaire, over 15% of the patients requested further help. Our findings suggest that training in adolescent health care and the provision of services to teenagers ought to include teaching in the area of spiritual and religious values of teenagers, with emphasis on the hospitalized adolescent.