The frequency and distribution of medium-sized neurons with indented nuclei in the primate and rodent neostriatum

Brain Res. 1985 Feb 18;327(1-2):307-11. doi: 10.1016/0006-8993(85)91524-0.


Nuclear morphology is known to distinguish two classes of medium-sized neurons in the neostriatum, spiny projection neurons which have an unindented nucleus and aspiny interneurons which exhibit enfoldings of their nuclear envelope. The frequency and distribution of medium-sized neostriatal neurons with indented nuclei were examined in the light microscope in semi-thick sections. Results showed that the proportion of neostriatal neurons with nuclear indentations was greater in the monkey (23%) than in the mouse and rat (4-5%). Also, nuclear enfoldings were found in more neurons of the monkey caudate than putamen, whereas in the rodent regional differences were not observed. Findings suggest that aspiny interneurons play a greater role in the integrative and functional organization of the neostriatum in the primate than in the rodent brain.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Caudate Nucleus / cytology
  • Caudate Nucleus / ultrastructure
  • Cell Nucleus / ultrastructure
  • Corpus Striatum / cytology*
  • Corpus Striatum / ultrastructure
  • Macaca / anatomy & histology*
  • Macaca fascicularis / anatomy & histology*
  • Mice / anatomy & histology*
  • Neurons / classification
  • Neurons / ultrastructure
  • Putamen / cytology
  • Putamen / ultrastructure
  • Rats / anatomy & histology*
  • Rats, Inbred Strains