How does chronic pain lead to memory loss?

Elife. 2025 Jan 27:14:e105633. doi: 10.7554/eLife.105633.

Authors

Suelen Pereira¹, Ivan Tomsic², Robson da Costa¹, Mychael V Lourenco^{2

3}

Affiliations

¹ School of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
² Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
³ Department of Biochemistry and Tissue Biology, Institute of Biology, State University of Campinas, Campinas, Brazil.

Abstract

A dysfunctional signaling pathway in the hippocampus has been linked to chronic pain-related memory impairment in mice.

Keywords: chronic pain; dentate gyrus; memory; mouse; neuroscience; sphingosine 1-phosphate; synaptic plasticity.

© 2025, Pereira et al.

Publication types

Editorial

MeSH terms

Animals
Chronic Pain* / complications
Chronic Pain* / physiopathology
Hippocampus* / physiopathology
Memory Disorders* / etiology
Memory Disorders* / physiopathology
Mice
Signal Transduction