Inter-laboratory quality control of estrogen and progesterone receptor assays in breast cancer tissue using lyophilised cytosols

Clin Biochem. 1985 Feb;18(1):20-6. doi: 10.1016/s0009-9120(85)80018-7.


In 1981 a quality control (QC) program for estrogen and progesterone receptor assays was organized among six laboratories in Ontario, Canada. Twenty-three vials of lyophilised cytosol prepared from human breast tumor tissues were analysed by each laboratory over a two-year period. Samples of each batch of QC material were analysed at least twice: either in the same batch or on separate occasions. The present study demonstrates the stability of the QC material, defines the relative accuracy of the receptor assays, and provides estimates of within-batch and between-batch precision of the receptor assays.

Publication types

  • Comparative Study

MeSH terms

  • Breast Neoplasms / analysis*
  • Canada
  • Cytosol / analysis
  • Female
  • Freeze Drying
  • Humans
  • Laboratories
  • Quality Control
  • Receptors, Estrogen / analysis*
  • Receptors, Progesterone / analysis*


  • Receptors, Estrogen
  • Receptors, Progesterone