Varicella-Zoster virus associated vasculopathy in a young male multiple sclerosis patient, treated with dimethyl fumarate

Acta Neurol Belg. 2025 Jun;125(3):875-878. doi: 10.1007/s13760-025-02723-0. Epub 2025 Jan 28.

Abstract

With the increasing use of disease modifying therapies as treatment for multiple sclerosis, knowledge of the rare but possibly severe adverse events becomes increasingly important. We present a case of Varicella-Zoster virus associated vasculopathy in a young male multiple sclerosis patient, treated with dimethyl fumarate. We aim to address this rare but potentially deadly complication of varicella-Zoster virus infection and spread awareness about the increased risk in this patient population.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Adult
  • Dimethyl Fumarate* / adverse effects
  • Dimethyl Fumarate* / therapeutic use
  • Herpesvirus 3, Human*
  • Humans
  • Immunosuppressive Agents* / adverse effects
  • Male
  • Multiple Sclerosis* / complications
  • Multiple Sclerosis* / drug therapy
  • Multiple Sclerosis, Relapsing-Remitting* / drug therapy
  • Varicella Zoster Virus Infection* / complications

Substances

  • Dimethyl Fumarate
  • Immunosuppressive Agents