Mouse gut blueprint: regionality and resilience

Qiwei Ge; Shujie Chen

doi:10.1016/j.it.2025.01.004

Mouse gut blueprint: regionality and resilience

Trends Immunol. 2025 Feb;46(2):94-96. doi: 10.1016/j.it.2025.01.004. Epub 2025 Jan 28.

Authors

Qiwei Ge¹, Shujie Chen²

Affiliations

¹ Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310058, China; Institution of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang Province, 310058, China.
² Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang Province, 310058, China; Institution of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang Province, 310058, China. Electronic address: chenshujie77@zju.edu.cn.

PMID: 39880712
DOI: 10.1016/j.it.2025.01.004

Abstract

Mayassi and colleagues utilized spatial transcriptomics to create a comprehensive blueprint of the mouse gut, exploring its adaptability and resilience under perturbed conditions. Their work highlights the adaptive capabilities of the murine gut's regionalized structure, providing insights into how it functions in a coordinated manner and how it responds to external challenges.

MeSH terms

Animals
Gastrointestinal Microbiome* / immunology
Gastrointestinal Tract / immunology
Gastrointestinal Tract / physiology
Humans
Mice
Transcriptome