Subcellular mitochondrial heterogeneity enables opposing metabolic demands

Brandon Chen; Yatrik M Shah; Costas A Lyssiotis

doi:10.1016/j.tem.2025.01.003

Subcellular mitochondrial heterogeneity enables opposing metabolic demands

Trends Endocrinol Metab. 2025 Mar;36(3):202-204. doi: 10.1016/j.tem.2025.01.003. Epub 2025 Jan 28.

Authors

Brandon Chen¹, Yatrik M Shah², Costas A Lyssiotis³

Affiliations

¹ Cellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
² Cellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, Division of Gastroenterology and Hepatology, Michigan Medicine at the University of Michigan, Ann Arbor, MI 48109, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
³ Cellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, Division of Gastroenterology and Hepatology, Michigan Medicine at the University of Michigan, Ann Arbor, MI 48109, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: clyssiot@umich.edu.

PMID: 39880788
PMCID: PMC11879766 (available on 2026-03-01)
DOI: 10.1016/j.tem.2025.01.003

Abstract

Mitochondria perform essential metabolic processes that sustain cellular bioenergetics and biosynthesis. In a recent article, Ryu et al. explored how mitochondria coordinate biochemical reactions with opposing redox demands within the same cell. They demonstrate that subcellular mitochondrial heterogeneity enables metabolic compartmentalization to permit concurrent oxidative ATP production and reductive proline biosynthesis.

Keywords: metabolic compartmentalization; mitochondria dynamics; mitochondrial ultrastructure; organelle communication; proline metabolism.

Publication types

Review

MeSH terms

Adenosine Triphosphate / metabolism
Animals
Energy Metabolism* / physiology
Humans
Mitochondria* / metabolism
Oxidation-Reduction

Substances

Adenosine Triphosphate

Abstract

Publication types

MeSH terms

Substances

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