Deep Brain Stimulation for Substance Use Disorder: Case Report of Fentanyl Use Disorder and Review of the Literature

Andrew Z Yang; James MacKillop; Alexandre Boutet; Anton Fomenko; Artur Vetkas; Matthew E Sloan; Can Sarica; Brendan Santyr; Dana Abdel Hafeez; Sharmane Villafuerte; Jürgen Germann; Ivan Skelin; Luka Milosevic; Benjamin Davidson; Suneil K Kalia; Taufik A Valiante; Andres M Lozano; Victor M Tang

doi:10.1017/cjn.2025.12

Deep Brain Stimulation for Substance Use Disorder: Case Report of Fentanyl Use Disorder and Review of the Literature

Can J Neurol Sci. 2025 Jan 30:1-4. doi: 10.1017/cjn.2025.12. Online ahead of print.

Authors

Andrew Z Yang^{1

2

3}, James MacKillop^{3

4

5}, Alexandre Boutet^{6

7}, Anton Fomenko¹, Artur Vetkas¹, Matthew E Sloan^{2

8

9

10

11

12

13}, Can Sarica¹, Brendan Santyr¹, Dana Abdel Hafeez¹⁴, Sharmane Villafuerte¹, Jürgen Germann^{1

7

15}, Ivan Skelin¹⁵, Luka Milosevic^{7

15

16

17

18}, Benjamin Davidson^{1

19

20}, Suneil K Kalia^{1

7

15

18}, Taufik A Valiante^{1

7

12

15

16

18

21}, Andres M Lozano^{1

7

12

15

18}, Victor M Tang^{2

8

10

12

13}

Affiliations

¹ Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
² Addictions Division, Centre for Addiction and Mental Health, Toronto, ON, Canada.
³ Peter Boris Centre for Addictions Research, McMaster University & St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
⁴ Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, ON, Canada.
⁵ Michael G. DeGroote Centre for Medicinal Cannabis Research, McMaster University & St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
⁶ Joint Department of Medical Imaging, University of Toronto, Toronto, ON, Canada.
⁷ Center for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, ON, Canada.
⁸ Division of Neurosciences and Clinical Translation, Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
⁹ Department of Pharmacology & Toxicology, University of Toronto, Toronto, ON, Canada.
¹⁰ Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
¹¹ Department of Psychological Clinical Science, University of Toronto Scarborough, Toronto, ON, Canada.
¹² Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
¹³ Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, ON, Canada.
¹⁴ Division of Neurosurgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada.
¹⁵ Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
¹⁶ Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
¹⁷ University of Toronto - Max Planck Centre for Neural Science and Technology, University of Toronto, Toronto, ON, Canada.
¹⁸ KITE Research Institute, University Health Network, Toronto, ON, Canada.
¹⁹ Harquail Centre for Neuromodulation, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada.
²⁰ Sunnybrook Research Institute, Toronto, ON, Canada.
²¹ Department of Electrical and Computer Engineering, University of Toronto, Toronto, ON, Canada.

PMID: 39882576
DOI: 10.1017/cjn.2025.12

No abstract available

Keywords: addiction; basal ganglia; brain stimulation; clinical neurosciences; neuropsychiatry; neurosciences; neurosurgery; psychiatry; radiosurgery; stereotactic surgery.