Outcome measures in rodent models for spinal cord injury and their human correlates

Abstract

Pre-clinical research is intended to inform clinical research, however, communication between these researchers is lacking. A better understanding of what can be learned from animal and human models and what cannot, is essential. This includes a better understanding of where underlying constructs in outcome measures in rodents and humans align and where they diverge to improve dialogue between human and animal researchers. The goal of this review is to promote an understanding of similarities and differences in outcome measures and encourage consideration of these differences when planning, interpreting, and communicating findings from animal or human experiments. Seven individuals with a range of expertise in human and animal research and outcome measures reviewed rat and human measures focused on sensorimotor and functional outcomes. They then discussed where measures corresponded and where they did not, based on the underlying construct the assessment is intended to measure. Key findings are that measures of impairment (such as strength) often used in clinical trials are not commonly used in rodents. Measures such as speed and distance of locomotion are commonly assessed in humans and, while not commonly assessed in rodents, can be collected through existing outcome measures. Additional findings are that animal and human outcome measures are often developed and evaluated differently, with more standardized processes applied to human outcome measures. A deeper understanding and communication of similarities and differences in outcome measures, and where differences are necessary due to interspecies differences, may improve translation from animals to humans and humans to animals.

Keywords: Clinical; Outcome measures; Pre-clinical; Spinal cord injury; Translation.