Diagnostic approach to limbal stem cell deficiency

Daniella Lent-Schochet; Mizna Akbar; Joshua H Hou; Asim V Farooq

doi:10.3389/fopht.2024.1524595

Diagnostic approach to limbal stem cell deficiency

Front Ophthalmol (Lausanne). 2025 Jan 16:4:1524595. doi: 10.3389/fopht.2024.1524595. eCollection 2024.

Authors

Daniella Lent-Schochet¹, Mizna Akbar¹, Joshua H Hou², Asim V Farooq¹

Affiliations

¹ Department of Ophthalmology and Visual Science, University of Chicago, Chicago, IL, United States.
² Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minnesota, MN, United States.

Abstract

Limbal stem cell deficiency (LSCD) is an important cause of visual and ocular morbidity. Effective diagnosis and management require a thoughtful and comprehensive evaluation of the ocular surface. This review describes the pathogenesis, diagnosis, and grading of LSCD, as well as characteristic findings via slit lamp examination, in-vivo confocal microscopy, anterior segment optical coherence tomography (AS-OCT), impression cytology, and OCT angiography.

Keywords: anterior segment OCT; confocal micoscopy; impression cytology; limbal stem cell; limbal stem cell deficiency.

Publication types

Review

Grants and funding

K08 EY032097/EY/NEI NIH HHS/United States