Orthostatic effect of imipramine and doxepin in depressed geriatric outpatients

J Clin Psychopharmacol. 1985 Apr;5(2):102-6. doi: 10.1097/00004714-198504000-00009.


Blood pressure measurements were collected from 36 depressed geriatric outpatients (ages 55 to 81 years) enrolled in a double-blind, placebo-controlled study of the efficacy of doxepin and imipramine. Mean systolic postural changes were 25.9 mm Hg for imipramine, significantly higher than the 10.5 mm Hg for doxepin, and 12.4 mm Hg for placebo. The orthostatic drop in the imipramine group was only weakly related to dose and did not correlate with amount of pretreatment orthostatic hypotension or with duration of treatment. The increased orthostatic hypotension occurred early in treatment and at low doses of imipramine. Accordingly, caution is advised in the use of imipramine for the elderly.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age Factors
  • Aged
  • Depressive Disorder / drug therapy*
  • Double-Blind Method
  • Doxepin / adverse effects*
  • Female
  • Humans
  • Hypotension, Orthostatic / chemically induced*
  • Imipramine / adverse effects*
  • Male
  • Middle Aged


  • Doxepin
  • Imipramine