Role of the Microbiome in Neonatal Infection: Pathogenesis and Implications for Management

Abstract

The human microbiome refers to the collective genome of microorganisms, including bacteria, fungi, and viruses residing on human body surfaces that are in contact with the environment. Together these communities protect against invasive infections. Conversely, when disrupted, the microbiome can be the source of pathogens causing invasive infection. Interventions to manipulate it via probiotics, antibiotics, and fecal transplantation are available. The risk benefit of these interventions remains unclear. In this review, the authors discuss evidence linking the gut microbiome to neonatal sepsis and also discuss the challenges for translating this knowledge into better clinical care.

Keywords: Bacteremia; Bacterial meningitis; Colonization; Microbiome; Neonate; Preterm; Sepsis.