Abstract
In rats receiving a fat diet (75% Altromin R and 25% olive oil) ad libitum for 15 hours, an orally administered dose of 500 mg/kg L-carnitine produces: an increase in serum carnitine and acetyl-carnitine levels; a decrease in serum triglyceride (TG) and free fatty acid (FFA) levels; a normalization of the heart and liver carnitine pattern; a reduction of myocardial neutral lipase (NL) activity, without affecting lipoprotein lipase (LPL) of the heart. Under these experimentally-induced conditions, L-carnitine stimulates the excretion of acyl groups as acyl-carnitines with the urine. Acylcarnitines are practically absent from the urine of control animals.
MeSH terms
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Acetylcarnitine / blood
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Acylation
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Animals
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Carnitine / analogs & derivatives
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Carnitine / blood
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Carnitine / metabolism
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Carnitine / pharmacology*
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Carnitine / urine
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Dietary Fats / administration & dosage*
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Fatty Acids, Nonesterified / blood
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Feces / analysis
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Hyperlipidemias / blood
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Hyperlipidemias / metabolism*
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Hyperlipidemias / urine
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Kidney / metabolism
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Lipase / metabolism
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Lipoprotein Lipase / metabolism
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Liver / metabolism
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Male
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Myocardium / enzymology
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Myocardium / metabolism
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Rats
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Rats, Inbred Strains
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Tissue Distribution
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Triglycerides / blood
Substances
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Dietary Fats
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Fatty Acids, Nonesterified
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Triglycerides
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Acetylcarnitine
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Lipase
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Lipoprotein Lipase
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Carnitine