Three-dimensional structure of calmodulin

Nature. 1985 May 2-8;315(6014):37-40. doi: 10.1038/315037a0.

Abstract

The three-dimensional structure of calmodulin has been determined crystallographically at 3.0 A resolution. The molecule consists of two globular lobes connected by a long exposed alpha-helix. Each lobe binds two calcium ions through helix-loop-helix domains similar to those of other calcium-binding proteins. The long helix between the lobes may be involved in interactions of calmodulin with drugs and various proteins.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Allosteric Regulation
  • Animals
  • Binding Sites
  • Calcium / physiology*
  • Calmodulin* / metabolism
  • Male
  • Models, Molecular
  • Protein Conformation
  • Rats
  • Structure-Activity Relationship
  • Troponin
  • Troponin C

Substances

  • Calmodulin
  • Troponin
  • Troponin C
  • Calcium