CD4+ T-Cell Lymphoma Harboring a Chimeric Antigen Receptor Integration in TP53

Karlo Perica; Nayan Jain; Michael Scordo; Ruchi Patel; Ozgur Can Eren; Utsav Patel; Gunes Gundem; Dylan Domenico; Sneha Mitra; Nicholas D Socci; John K Everett; Aoife M Roche; Angelina Petrichenko; Gunjan L Shah; Maria E Arcila; Laetitia Borsu; Jae H Park; Steven M Horwitz; Sergio A Giralt; Ahmet Dogan; Christina Leslie; Elli Papaemmanuil; Frederic D Bushman; Saad Z Usmani; Michel Sadelain; Sham Mailankody

doi:10.1056/NEJMoa2411507

CD4+ T-Cell Lymphoma Harboring a Chimeric Antigen Receptor Integration in TP53

N Engl J Med. 2025 Feb 6;392(6):577-583. doi: 10.1056/NEJMoa2411507.

Authors

Karlo Perica^{1

2}, Nayan Jain², Michael Scordo^{1

3

4}, Ruchi Patel⁵, Ozgur Can Eren⁶, Utsav Patel⁷, Gunes Gundem⁸, Dylan Domenico⁸, Sneha Mitra⁹, Nicholas D Socci⁵, John K Everett¹⁰, Aoife M Roche¹⁰, Angelina Petrichenko¹⁰, Gunjan L Shah^{1

3

4}, Maria E Arcila⁷, Laetitia Borsu⁷, Jae H Park^{1

4

11}, Steven M Horwitz^{1

4

12}, Sergio A Giralt^{1

3

4}, Ahmet Dogan⁶, Christina Leslie⁹, Elli Papaemmanuil⁸, Frederic D Bushman¹⁰, Saad Z Usmani^{1

3

4

13}, Michel Sadelain², Sham Mailankody^{1

4

13}

Affiliations

¹ Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York.
² Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York.
³ Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York.
⁴ Department of Medicine, Weill Cornell Medical College, New York.
⁵ Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York.
⁶ Hematopathology Service, Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York.
⁷ Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York.
⁸ Computational Oncology Service, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York.
⁹ Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York.
¹⁰ Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
¹¹ Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York.
¹² Lymphoma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York.
¹³ Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York.

Abstract

Malignant T-cell transformation after chimeric antigen receptor (CAR) T-cell therapy has been described, but the contribution of CAR integration to oncogenesis is not clear. Here we report a case of a T-cell lymphoma harboring a lentiviral integration in a known tumor suppressor, TP53, which developed in a patient with multiple myeloma after B-cell maturation antigen (BCMA) CAR T-cell therapy.

Publication types

Case Reports

MeSH terms

B-Cell Maturation Antigen
CD4-Positive T-Lymphocytes / immunology
Humans
Immunotherapy, Adoptive*
Lentivirus / genetics
Lymphoma, T-Cell / immunology
Lymphoma, T-Cell / therapy
Male
Middle Aged
Multiple Myeloma / therapy
Receptors, Chimeric Antigen* / immunology
Tumor Suppressor Protein p53* / genetics

Substances

Receptors, Chimeric Antigen
Tumor Suppressor Protein p53
B-Cell Maturation Antigen
TP53 protein, human

Abstract

Publication types

MeSH terms

Substances

Grants and funding